Cadiolides J-M, antibacterial polyphenyl butenolides from the Korean tunicate Pseudodistoma antinboja

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• 作者：Weihong Wang^a ; ^e ; Hiyoung Kim^a ; ^e ; Rahul S. Patil^a ; Awadut G. Giri^a ; Dong Hwan Won^a ; Dongyup Hahn^a ; Youjung Sung^a ; Jusung Lee^a ; Hyukjae Choi^b ; Sang-Jip Nam^c ; Heonjoong Kang^a ; ^d ; ^{hjkang@snu.ac.kr}
• 关键词：Tunicate ; Pseudodistoma antinboja ; Antibacterial activity
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：27
• 期：3
• 页码：574-577
• 全文大小：526 K
• 卷排序：27

文摘

Activity-guided fractionations of the tunicate Pseudodistoma antinboja yielded four new compounds of the cadiolide class (cadiolides J–M, 1, 3–5) along with a known one (cadiolide H, 2). The structures were defined by spectroscopic methods including X-ray crystallographic analysis. These compounds were evaluated for their antibacterial activity and exhibited potent antibacterial activity against all of the drug resistant strains tested with MICs comparable to those of marketed drugs such as vancomycin and linezolid.