Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control

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• 作者：Christina Glytsou¹ ; ² ; ³ ; Enrique Calvo⁴ ; Sara Cogliati¹ ; ⁴ ; Arpit Mehrotra¹ ; Irene Anastasia¹ ; Giovanni Rigoni¹ ; Andrea Raimondi⁵ ; Norihito Shintani¹ ; ³ ; ⁶ ; Marta Loureiro⁴ ; Jesù ; s Vazquez⁴ ; Luca Pellegrini⁷ ; Jose Antonio Enriquez⁴ ; Luca Scorrano¹ ; ³ ; ⁸ ; ^{luca.scorrano@unipd.it} ; Maria Eugenia Soriano¹ ; ³ ; ^{mariaeugenia.soriano@unipd.it}
• 关键词：mitochondria ; cristae ; MICOS ; OPA1 ; proteomics
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：3024-3034
• 全文大小：3729 K
• 卷排序：17

文摘

Complexes containing OPA1 and MIC60 are targeted during cristae remodeling OPA1 lies upstream of MIC60 in regulating cristae junction number and stability OPA1 is the sole regulator of cristae junction width