Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes

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• 作者：Luciana G. da S. Souza^a ; Macia C.S. Almeida^a ; Telma L.G. Lemos^a ; ^{tlemos@ufc.br" class="auth_mail" title="E-mail the corresponding author} ; Paulo R.V. Ribeiro^b ; Edy S. de Brito^b ; Vera L.M. Silva^c ; Artur M.S. Silva^c ; ^{artur.silva@ua.pt" class="auth_mail" title="E-mail the corresponding author} ; Raimundo Braz-Filho^d ; José ; G.M. Costa^e ; Fá ; bio F.G. Rodrigues^e ; Francisco S. Barreto^f ; Manoel O. de Moraes^f
• 关键词：Biflorin ; Hydrazones ; Oximes ; Antibacterial ; Antitumoral
• 刊名：Bioorganic & Medicinal Chemistry Letters
• 出版年：2016
• 出版时间：15 January 2016
• 年：2016
• 卷：26
• 期：2
• 页码：435-439
• 全文大小：575 K

文摘

Biflorin 1 is a biologically active quinone, isolated from Capraria biflora. Five new biflorin-based nitrogen derivatives were synthesized, of which two were mixtures of (E)- and (Z)- isomers: (Z)-2a, (Z)-2b, (Z)-3a, (Z)- and (E)-3b, (Z)- and (E)-3c. The antibacterial activity was investigated using the microdilution method for determining the minimum inhibitory concentration (MIC) against six bacterial strains. Tests have shown that these derivatives have potential against all bacterial strains. The cytotoxic activity was also evaluated against three strains of cancer cells, but none of the derivatives showed activity.