Nanoparticle formulation having ability to control the release of protein for drug delivery application
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- 作者：Rajat Gupta rajat87gupta@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sanat Mohanty ; sanat.mohanty@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Folic acid ; Protein delivery ; Diabetes ; Control release ; Encapsulation
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：327-333
- 全文大小：716 K
文摘
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More than 95% of the total protein (BSA) can be encapsulated and released from folic acid nanoparticles having size between 200 and 300 nm.
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Release of BSA and carrier folic acid can be controlled by changing the concentration of crosslinking salt.
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Similar release patterns of protein and carrier folic acid suggest that particle is formed by FA-protein association.
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Release behavior of both folic acid and protein is dependent on salt concentration in the release medium.
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Release behavior of drug from folic acid nanoparticles is same irrespective of molecular weight of drug.