Route of administration of attenuated sporozoites is instrumental in rendering immunity against Plasmodia infection
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- 作者：Rajesh Parmar1 ; Hardik Patel1 ; Naveen Yadav ; Manoj Patidar ; Rajeev K. Tyagi ; Sarat Kumar Dalai ; sarat.dalai@nirmauni.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Radiation attenuated sporozoites (RAS) ; Circumsporozoite (CS) antigen ; CD8+ T cells ; Liver-stage (LS) antigen ; Plasmodium berghei ; Liver-stage malaria vaccine
- 刊名：Vaccine
- 出版年：2016
- 出版时间：14 June 2016
- 年：2016
- 卷：34
- 期：28
- 页码：3229-3234
- 全文大小：1585 K
文摘
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Development of sporozoites in the liver drives the expression of stage specific antigen.
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Intravenous administration of attenuated sporozoite confers long lived protection.
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Threshold of CD8+ T cells is inevitably required to induce sterile protection.
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CSP specific antibody prevents passage of sporozoite from skin to hepatocytes.
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Antigen load and antigen persistence in liver generates protective CD8+ T cells.