Automated identification of normal and diabetes heart rate signals using nonlinear measures
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- 作者：U. Rajendra Acharya ; Oliver Faust ; Nahrizul Adib Kadri ; Jasjit S. Suri ; Wenwei Yu
- 关键词：ApEn ; Approximate Entropy ; ANN ; Artificial neural network ; ApEn ; Approximate Entropy ; CAD ; Computer-aided diagnosis ; DFA ; Detrended fluctuation analysis ; DM ; Diabetes mellitus ; DT ; Decision tree ; ECG ; Electrocardiogram ; FIS ; Fuzzy inference system ; FSC ; F
- 刊名：Computers in Biology and Medicine
- 出版年：2013
- 出版时间：1 October, 2013
- 年：2013
- 卷：43
- 期：10
- 页码：1523-1529
- 全文大小：521 K
文摘
Diabetes mellitus (DM) affects considerable number of people in the world and the number of cases is increasing every year. Due to a strong link to the genetic basis of the disease, it is extremely difficult to cure. However, it can be controlled to prevent severe consequences, such as organ damage. Therefore, diabetes diagnosis and monitoring of its treatment is very important. In this paper, we have proposed a non-invasive diagnosis support system for DM. The system determines whether or not diabetes is present by determining the cardiac health of a patient using heart rate variability (HRV) analysis. This analysis was based on nine nonlinear features namely: Approximate Entropy (ApEn), largest Lyapunov exponet (LLE), detrended fluctuation analysis (DFA) and recurrence quantification analysis (RQA). Clinically significant measures were used as input to classification algorithms, namely AdaBoost, decision tree (DT), fuzzy Sugeno classifier (FSC), k-nearest neighbor algorithm (k-NN), probabilistic neural network (PNN) and support vector machine (SVM). Ten-fold stratified cross-validation was used to select the best classifier. AdaBoost, with least squares (LS) as weak learner, performed better than the other classifiers, yielding an average accuracy of 90 % , sensitivity of 92.5 % and specificity of 88.7 % .