Phosphorylation negatively regulates exosome mediated secretion of cryAB in glioma cells
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- 作者：Rajshekhar A. Kore ; Edathara C. Abraham ; AbrahamEdatharaC@uams.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Exosomes ; cryAB ; Phosphorylation ; Glycosylation ; Glioblastoma multiforme
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：1863
- 期：2
- 页码：368-377
- 全文大小：1716 K
文摘
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PTMs dictate cellular localization and functions of many proteins.
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PTMs determine cellular localization and exosomal secretion of cryAB.
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Phosphorylation of cryAB at Ser19 leads to formation of cytosolic inclusions.
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Phosphorylation of cryAB deters its packaging into vesicles for exosomal secretion.
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Preventing glycosylation also deters packaging & exosomal secretion of cryAB.