Synthesis and antimicrobial evaluation of novel ethyl 2-(2-(4-substituted)acetamido)-4-subtituted-thiazole-5-carboxylate derivatives
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- 作者：Chandrakant D. Pawar<sup>asup><sup> ; sup><sup>dbschandrakant15@rediffmail.com" class="auth_mail" title="E-mail the corresponding authorsup> ; Aniket P. Sarkate<sup>asup> ; Kshipra S. Karnik<sup>asup> ; Sushilkumar S. Bahekar<sup>bsup> ; Dattatraya N. Pansare<sup>asup> ; Rohini N. Shelke<sup>csup> ; Chetan S. Jawale<sup>dsup> ; Devanand B. Shinde<sup>esup>
- 关键词：Thiazole ring ; Antibacterial activity ; Antifungal activity
- 刊名：Bioorganic & Medicinal Chemistry Letters
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：26
- 期：15
- 页码：3525-3528
- 全文大小：396 K
文摘
A series of novel molecules containing thiazole ring structure were designed and synthesized. The structures of the synthesized compounds were elucidated and confirmed by <sup>1sup>H NMR, <sup>13sup>C NMR, Mass spectrum and the purity was checked through HPLC analysis. Among these synthesized compounds, <strong class="boldFont">3astrong>–<strong class="boldFont">3istrong> and <strong class="boldFont">6astrong>–<strong class="boldFont">6cstrong> were tested for their antimicrobial activity (minimum inhibitory concentration) against a series of strains of Bacillus subtilis, Staphylococcus aureus and Escherichia coli for antibacterial activity and against the strains of Candida albicans, Aspergillus flavus and Aspergillus niger for antifungal activity respectively. The results of the antimicrobial screening data revealed that most of the tested compounds showed moderate to good microbial inhibitions.