Effect of selective estrogen receptor modulators on metabolic homeostasis
详细信息 查看全文
- 作者：Beibei Xu ; Dragana Lovre ; Franck Mauvais-Jarvis ; fmauvais@tulane.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Selective estrogen receptor modulators ; Tissue-selective estrogen complex ; Bazedoxifene ; Metabolic syndrome ; Energy metabolism ; Diabetes
- 刊名：Biochimie
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：124
- 期：Complete
- 页码：92-97
- 全文大小：304 K
文摘
- •
SERMs exhibit tissue-specific estrogen agonistic or antagonistic activity.
- •
The SERMs include tamoxifen, raloxifene and bazedoxifene.
- •
Tamoxifen predisposes to diabetes, lipid abnormalities and hepatic steatosis.
- •
Raloxifene exhibits minor effects on metabolic homeostasis.
- •
Bazedoxifene combined with conjugated estrogens prevents menopausal metabolic dysfunction in mice.