The Antivascular Action of Physiotherapy Ultrasound on A Murine Tumor: Role of A Microbubble Contrast Agent

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• 作者：Andrew K.W. Wood ; Ralph M. Bunte ; Jennie D. Cohen ; Jeff H. Tsai ; William M.-F. Lee ; Ch ; ra M. Sehgal
• 关键词：Microvascular ultrasound imaging ; Cancer therapy ; Physiotherapy ; Antivascular ; Tumor angiogenesis ; Power Doppler ; Ultrasound bioeffects ; Microbubble contrast agent ; Vascular disrupting agents
• 刊名：Ultrasound in Medicine and Biology
• 出版年：2007
• 出版时间：December 2007
• 年：2007
• 卷：33
• 期：12
• 页码：1901-1910
• 全文大小：1542 K

文摘

This study investigated whether a microbubble-containing ultrasound contrast agent had a role in the antivascular action of physiotherapy ultrasound on tumor neovasculature. Ultrasound images (B-mode and contrast-enhanced power Doppler [0.02 mL Definity]) were made of 22 murine melanomas (K1735²²). The tumor was insonated (I_SATA = 1.7 W cm^–2, 1 MHz, continuous output) for 3 min and the power Doppler observations of the pre- and postinsonation tumor vascularities were analyzed. Significant reductions (p = 0.005 for analyses of color-weighted fractional area) in vascularity occurred when a contrast-enhanced power Doppler study occurred before insonation. Vascularity was unchanged in tumors without a pretherapy Doppler study. Histologic studies revealed tissue structural changes that correlated with the ultrasound findings. The underlying etiology of the interaction between the physiotherapy ultrasound beam, the microbubble-containing contrast agent and the tumor neovasculature is unknown. It was concluded that contrast agents play an important role in the antivascular effects induced by physiotherapy ultrasound. (E-mail: mailto:sehgalc@uphs.upenn.edu"">sehgalc@uphs.upenn.edu)