Betulinic acid derived hydroxamates and betulin derived carbamates are interesting scaffolds for the synthesis of novel cytotoxic compounds
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- 作者：Jana Wiemann ; Lucie Heller ; Vincent Perl ; Ralph Kluge ; Dieter Strö ; hl ; René ; Csuk ; rene.csuk@chemie.uni-halle.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Triterpenes ; Betulinic acid ; Betulin ; Hydroxamates ; Carbamates ; Tumor cells
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2015
- 出版时间：1 December 2015
- 年：2015
- 卷：106
- 期：Complete
- 页码：194-210
- 全文大小：980 K
文摘
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We investigated hydroxamates and carbamates of betulin and betulinic acid.
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The compounds showed antitumor activity on different human cancer cell lines.
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Many of the compounds are cytotoxic even in a low micro molar concentration.
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Highest cytotoxicity was found for a betulinic acid derived hydroxamate.
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Highest selectivity was established for a betulin derived N-hexylcarbamate.