Transcriptional networks associated with the immune system are disrupted by organochlorine pesticides in largemouth bass (Micropterus salmoides) ovary
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- 作者：Christopher J. Martyniuk ; 1 ; cmartyn@ufl.edu" class="auth_mail" title="E-mail the corresponding author ; ndenslow@ufl.edu" class="auth_mail" title="E-mail the corresponding author ; Nicholas J. Doperalski1 ; April Feswick ; Melinda S. Prucha ; Kevin J. Kroll ; David S. Barber ; Nancy D. Denslow
- 关键词：Immunosuppression ; Apex predator ; T-cells ; Reproductive axis ; Legacy pesticides
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：177
- 期：Complete
- 页码：405-416
- 全文大小：2815 K
文摘
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Female largemouth bass were fed p,p’ DDE, methoxychlor, and flutamide for three months.
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These OCPs and flutamide can act to antagonize the androgen receptor.
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The ovary accumulated three times more contaminant than the muscle.
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Reproductive endpoints, such as oocyte development, plasma steroids and vitellogenin were not altered.
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Gene network analysis suggested that the immune system may be a major target for OCPs.