Atrial fibrillation without comorbidities: Prevalence, incidence and prognosis (from the Framingham Heart Study)

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• 作者：Eun-Jeong Kim ; MD^a ; Xiaoyan Yin ; PhD^b ; Joã ; o D. Fontes ; MD^b ; Jared W. Magnani ; MD ; MSc^b ; ^c ; Steve A. Lubitz ; MD ; MPH^d ; ^e ; David D. McManus ; MD ; ScM^f ; Sudha Seshadri ; MD^b ; ^g ; Ramachandran S. Vasan ; MD^b ; ^c ; ^h ; Patrick T. Ellinor ; MD ; PhD^d ; ^e ; Martin G. Larson ; ScD^b ; ⁱ ; ^j ; Emelia J. Benjamin ; MD ; ScM^b ; ^c ; ^h ; ^k ; Michiel Rienstra ; MD ; PhD^l ; ^{m.rienstra@umcg.nl" class="auth_mail" title="E-mail the corresponding author}
• 刊名：American Heart Journal
• 出版年：2016
• 出版时间：July 2016
• 年：2016
• 卷：177
• 期：Complete
• 页码：138-144
• 全文大小：262 K

文摘

The epidemiology of atrial fibrillation (AF) without comorbidities, known as ‘lone AF’, is uncertain. Although it has been considered a benign condition, we hypothesized that it confers a worse prognosis compared with a matched sample without AF.

Methods

We described the proportion of AF without comorbidities (clinical, subclinical cardiovascular disease and triggers) among the entire AF sample in Framingham Heart Study (FHS). We compared AF without comorbidities with typical AF, and age-, sex- and cohort-matched individuals without AF, using Cox proportional hazards analysis in relation to combined cardiovascular events (stroke, heart failure, myocardial infarction), and mortality.

Results

Of 10,311 FHS participants, 1,961 were diagnosed with incident AF, among which 173 individuals had AF without comorbidities (47% women, mean age 71±12 years). AF without comorbidities had a prevalence of 1.7% of the entire cohort, and an annual incidence of 0.5 per 1000 person-years. During a median follow-up of 9.7 years after initial AF, 137 individuals with AF without comorbidities (79.2%) died and 141 individuals developed cardiovascular events (81.5%). AF without comorbidities had significantly lower mortality (HR 0.67, 95%CI 0.55-0.81, P < .001) and total cardiovascular events (HR 0.66, 95% CI 0.55-0.80, P < .001) compared with typical AF. However, mortality (HR1.43, 95% CI 1.18-1.75, P < .001) and risk of total cardiovascular events (HR 1.73, 95% CI 1.39-2.16, P < .001) were higher than age-, sex-, and cohort-matched individuals without AF.

Conclusions

The risk of cardiovascular outcomes and mortality among individuals with AF without comorbidities is lower than typical AF, but is significantly elevated compared with matched individuals without AF.