Vitamin D¨Cgene interactions in multiple sclerosis

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• 作者：Antonio J.  ; Berlanga-Taylor^a ;   ; ^c ; Giulio  ; Disanto^a ;   ; ^b ; George C.  ; Ebers^a ;   ; ^b ;   ; ^{george.ebers@clneuro.ox.ac.uk} ; Sreeram V.  ; Ramagopalan^a ;   ; ^b
• 关键词：Vitamin D ; Multiple sclerosis ; Gene&ndash ; environment interactions
• 刊名：Journal of the Neurological Sciences
• 出版年：2011
• 出版时间：15 December 2011
• 年：2011
• 卷：311
• 期：1-2
• 页码：32-36
• 全文大小：575 K

文摘

Vitamin D has been studied for over a century and its functions related to calcium homeostasis are well established. Over the last 30 years or so it has become increasingly clear that it has a wider role in physiology and, importantly, also in disease. Vitamin D deficiency has been linked to multiple sclerosis (MS); however the molecular mechanisms of this association were poorly understood. Recent technological advances have provided major insights as to how vitamin D may exert its role, particularly through the actions of the vitamin D receptor (VDR). In this review we aim to highlight the importance of the interaction between vitamin D and MS associated genes which provide a biological basis for the association between vitamin D and MS risk.