Biocomposite nanofibrous scaffolds fabricated bead free, uniform and possess rough fiber surface Aloe Vera and MgO nanoparticles initiates cell adhesion and proliferation CUR (1%)/MgO nanoparticle showed higher level of cell inhibition of MCF-7 cells compared to all other nanofibrous scaffolds PLACL/AV/MgO/CUR nanofibrous scaffolds proved to be a potential material system for cancer therapy