A review of toxicity from topical salicylic acid preparations

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• 作者：Raman K. Madan ; MD^a ; ^b ; Jacob Levitt ; MD^b ; ^{jacob.levitt@mssm.edu" class="auth_mail}
• 关键词：ichthyosis ; psoriasis ; salicylic acid ; salicylism ; skin absorption ; topical ; toxicity
• 刊名：Journal of the American Academy of Dermatology
• 出版年：April, 2014
• 年：2014
• 卷：70
• 期：4
• 页码：788-792
• 全文大小：228 K

文摘

Topical salicylic acid is often used in dermatologic conditions because of its keratolytic, bacteriostatic, fungicidal, and photoprotective properties. The bioavailability of salicylic acid differs depending on the vehicle used and pH of transcellular fluids. Although rare, salicylic acid toxicity (salicylism) can occur from topical application. Physicians should be mindful of the potential for salicylism or even death from topically applied salicylic acid.