Advanced endometrial cancer with serous metastasis in a 17-year-old

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• 作者：David E. Cohn ; Kimberly E. Resnick ; Nilsa C. Ramirez and Carl D. Morrison
• 刊名：Gynecologic Oncology
• 出版年：2006
• 出版时间：May 2006
• 年：2006
• 卷：101
• 期：2
• 页码：356-359
• 全文大小：273 K

文摘

class=""h4"">Background

Endometrial cancers with a component of serous histology generally occur in postmenopausal women and can present with advanced disease even in the absence of a deeply myoinvasive primary malignancy. We present a case of stage IIIC endometrial cancer with serous histology in a 17-year-old.

class=""h4"">Case

A 17-year-old presented with menorrhagia requiring blood transfusion and a transvaginal ultrasound demonstrated a 31 mm endometrial stripe within a bulky uterus. Endometrial curettage revealed a grade 2 endometrioid adenocarcinoma. The patient desired definitive surgical management for her disease; a stage IIIC endometrial cancer with focal low-grade serous carcinoma among a grade 2 endometrioid carcinoma was noted to be superficially myoinvasive. Multiple pelvic lymph nodes had evidence of metastatic serous adenocarcinoma. Platinum-based chemotherapy was administered, and the patient is without disease 24 months following therapy.

class=""h4"">Conclusion

Advanced endometrial cancer with metastasis of serous carcinoma to the retroperitoneal lymph nodes can occur, albeit extraordinarily rarely, in very young women. This information is critically important when counseling a woman regarding conservative management of endometrial adenocarcinoma with the interest of preservation of her fertility.