Noble metal nanoparticle-induced oxidative stress modulates tumor associated macrophages (TAMs) from an M2 to M1 phenotype: An in vitro approach
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- 作者：Ramkrishna Pala ; Biswajit Chakrabortya ; Anupam Natha ; Leichombam Mohindro Singha ; Mohammed Alib ; Dewan Shahidur Rahmanb ; Sujit Kumar Ghoshb ; Abhishek Basuc ; Sudin Bhattacharyac ; Rathindranath Barald ; Mahuya Senguptaa ; senguptamahuya35@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Noble metal nanoparticles ; Gold nanoparticles ; Silver nanoparticles ; Chemical carcinogen ; TAMs ; ROS ; RNS
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：332-341
- 全文大小：1852 K
文摘
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Noble metal (Au and Ag) nanoparticles modulate tumor associated macrophage (TAM).
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They trigger antitumorigenic signaling cascades in TAMs through ROS and RNS production.
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Protumorigenic nature of TAMs is altered in a radical shift by modulating regulatory cytokines.