Randomized controlled antiepileptic drug trials miss almost all patients with ongoing seizures

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• 作者：Bernhard J. Steinhoff ; ^{bsteinhoff@epilepsiezentrum.de} ; Anke M. Staack ; Barbara C. Hillenbrand
• 关键词：Epilepsy ; Antiepileptic drugs ; Randomized controlled trials ; Practical value
• 刊名：Epilepsy & Behavior
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：66
• 期：Complete
• 页码：45-48
• 全文大小：208 K
• 卷排序：66

文摘

Retrospective study Incidence of drug-resistant patients Proportion of these patients appropriate for the last phase II and III AED trials 18 of 216 patients (8.3%) would have been acceptable for recruitment. This may be one reason for the disappointing efficiency of many new AEDs after launch