Lipopolysaccharide-induced functional and structural injury of the mitochondria in the nigrostriatal pathway
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- 作者：Randy Hunter<sup>asup> ; Uttam Ojha<sup>bsup> ; Sunil Bhurtel<sup>bsup> ; Guoying Bing<sup>asup> ; Dong-Young Choi<sup>bsup><sup> ; sup><sup>dychoi@yu.ac.krsup>
- 关键词：Parkinson&rsquo ; s disease ; Neuroinflammation ; Mitochondria ; Lipopolysaccharide ; Oxidative stress
- 刊名：Neuroscience Research
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：114
- 期：Complete
- 页码：62-69
- 全文大小：1999 K
- 卷排序：114
文摘
Striatal injection of LPS caused dopaminergic neurodegeneration. Functional deficit was detected in the mitochondria. In the mitochondria, structural damage and oxidative modification were observed. Mitochondrial injury is related to the neuronal loss.