Diterpene alkaloids and diterpenes from Spiraea japonica and their anti-tobacco mosaic virus activity

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• 作者：Yuan Ma^a ; ^b ; ¹ ; Xin-Ying Mao^b ; ¹ ; Lie-Jun Huang^b ; Yi-Min Fan^a ; ^b ; Wei Gu^b ; Chen Yan^b ; Tao Huang^b ; Jian-Xin Zhang^b ; Chun-Mao Yuan^b ; ^{yuanchunmao01@126.com" class="auth_mail" title="E-mail the corresponding author} ; Xiao-Jiang Hao^b ; ^{haoxj@mail.kib.ac.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Spiraea japonica ; Atisine-type diterpene alkaloids ; Atisane-type diterpenes ; Anti-TMV activities
• 刊名：Fitoterapia
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：109
• 期：Complete
• 页码：8-13
• 全文大小：563 K

文摘

Five new naturally occurring natural products, including two atisine-type diterpene alkaloids (1 and 2), two atisane-type diterpenes (3 and 4), and a new natural product spiramine C2 (5), along with nine known ones (6–14), were isolated from the ethanolic extracts of the whole plant of Spiraea japonica var. acuminata Franch. Their structures were elucidated by extensive spectroscopic analysis. The anti-tobacco mosaic virus (TMV) activities of all the compounds were evaluated by the conventional half-leaf method. Six compounds (2, 3, 6, 7, 11, and 12) exhibited moderate activities at 100 μg/mL with inhibition rates in the range of 69.4–92.9%, which were higher than that of the positive control, ningnanmycin. Their preliminary structure–activity relationships were also discussed.