Benzimidazole-core as an antimycobacterial agent
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- 作者：Rangappa S. Keri ; keriphd@gmail.com" class="auth_mail" title="E-mail the corresponding author ; sk.rangappa@jainuniversity.ac.in" class="auth_mail" title="E-mail the corresponding author ; kerichem@rediffmail.com" class="auth_mail" title="E-mail the corresponding author ; Chethana Kolambae Rajappa ; Siddappa A. Patil ; Bhari Mallanna Nagaraja
- 关键词：AIDS ; acquired immunodeficiency syndrome ; DNA ; deoxyribonucleic acid ; EMB ; ethambuthol ; GI ; growth inhibition ; HIV ; human immunodeficiency virus ; HTS ; high throughput screening ; INH ; isoniazid ; LTBI ; latent tuberculosis infection ; MABA ; micro plate alamar blue assay ; M. africanum ; mycobacterium africanum ; M. bovis ; mycobacterium bovis ; M. caprae ; mycobacterium caprae ; MDR ; multidrug-resistant ; MIC ; minimal inhibitory concentration ; Mtb ; mycobacterium tuberculosis ; NR-Mtb ; non-replicating Mycobac
- 刊名：Pharmacological Reports
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：68
- 期：6
- 页码：1254-1265
- 全文大小：3046 K
文摘
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Benzimidazole core is an attractive target for drug development.
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In this review we discussed benzimidazole as antitubercular agent.
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Review analyzes structural requirements of benzimidazole as anti-TB agents, with SAR study.
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Review will be helpful for new thoughts in the quest for rational designs anti-TB drugs.