Thiol oxidation and di-tyrosine formation in human plasma proteins induced by inflammatory concentrations of hypochlorous acid

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• 作者：Graziano Colombo^a ; ^{graziano.colombo@unimi.it} ; Marco Clerici^a ; Alessandra Altomare^b ; Francesco Rusconi^c ; Daniela Giustarini^d ; Nicola Portinaro^e ; Maria Lisa Garavaglia^a ; Ranieri Rossi^d ; Isabella Dalle-Donne^a ; Aldo Milzani^a
• 关键词：Hypochlorous acid ; Protein thiols ; Protein carbonyls ; Di-tyrosine ; Protein aggregates
• 刊名：Journal of Proteomics
• 出版年：2017
• 出版时间：30 January 2017
• 年：2017
• 卷：152
• 期：Complete
• 页码：22-32
• 全文大小：861 K
• 卷排序：152

文摘

HOCl induces human serum albumin (HSA) Cys34 oxidation and protein carbonylation. Transthyretin, haptoglobin and α1-antitrypsin undergo HOCl-induced thiol oxidation. HOCl induces formation of high molecular weight (HMW) aggregates. Fibrinogen plays a significant role in the formation of HMW cross-linked aggregates.