Characteristics and Clinical Course of STEMI Patients who Received no Reperfusion in the Australia and New Zealand SNAPSHOT ACS Registry

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• 作者：Ahmad Farshid ; BMBS ; FRACP^a ; ^{afarshid@tpg.com.au" class="auth_mail" title="E-mail the corresponding author} ; David Brieger ; MBBS ; PhD ; FRACP^b ; Karice Hyun ; BSc ; MAppStat^c ; Christopher Hammett ; MBChB ; MD ; FRACP^d ; Christopher Ellis ; MBBS ; FRACP^e ; Jamie Rankin ; MBBS ; FRACP^f ; Jeff Lefkovits ; MBBS ; FRACP^g ; Derek Chew ; MBBS ; MPH ; FRACP^h ; John French ; MBBS ; PhD ; FRACPⁱ
• 关键词：ST elevation myocardial infarction ; Reperfusion therapy ; Primary percutaneous coronary intervention ; Thrombolysis
• 刊名：Heart, Lung and Circulation
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：25
• 期：2
• 页码：132-139
• 全文大小：413 K

文摘

Cohort studies of STEMI patients have reported that over 30% receive no reperfusion. Barriers to greater use of reperfusion in STEMI patients require further elucidation.

Methods

We collected data on STEMI patients with no reperfusion as part of the SNAPSHOT ACS Registry, which recruited consecutive ACS patients in 478 hospitals throughout Australia and New Zealand during 14-27 May 2012.

Results

Of 4387 patients enrolled, 419 were diagnosed with STEMI. Primary PCI (PPCI) was performed in 160 (38.2%), fibrinolysis was used in 105 (25.1%), and 154 (36.7%) had no reperfusion. Patients with no reperfusion had a mean age of 70.3±15.0 years compared with 63.1±13.5 in the reperfusion group (p<0.0001). There were more females in the no reperfusion group (37.1% v 23.0% p=0.002) and they were significantly more likely to have prior PCI or CABG, heart failure, atrial fibrillation, chronic kidney disease and other vascular disease, and to be nursing home residents (all p<0.05). Patients without reperfusion had a significantly higher mortality in hospital (11.7% v 4.9%, p=0.011). In 370 patients who presented within 12 hours, 28 had early angiography without PCI, which was considered an attempt at reperfusion. Therefore reperfusion was attempted in 293 of 370 eligible patients (79.2%).

Conclusion

Of consecutive STEMI patients, 36.7% did not receive any reperfusion and they had a higher risk of death in hospital. In eligible patients, reperfusion was attempted in 79.2%. National strategies to encourage earlier medical contact and greater use of reperfusion in eligible patients may lead to better outcomes.