Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway
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- 作者：Ge Xua ; 1 ; Lili Fenga ; 1 ; Pingping Songb ; 1 ; Fang Xua ; Ang Lia ; Yubin Wangc ; Yan Shena ; Xuefeng Wua ; Qiong Luoa ; Xingxin Wua ; Yang Suna ; Xudong Wua ; xudongwu@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Qiang Xua ; molpharm@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Isomeranzin ; Anti-inflammation ; M1 macrophage polarization ; NF-κB signals
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：38
- 期：Complete
- 页码：175-185
- 全文大小：2812 K
文摘
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We identified the anti-inflammatory property of isomeranzin isolated from Murraya exotica for the first time.
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The anti-inflammatory activity of isomeranizn was due to its inhibition on M1 polarization.
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Potential mechanism of isomeranizn relied on the down-regulation of NF-κB and ERK signals.
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Isomeranzin ameliorated various inflammatory diseases, including sepsis and DSS or TNBS induced colitis.