刊名:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
出版年:2017
出版时间:January 2017
年:2017
卷:1864
期:1
页码:62-75
全文大小:3667 K
卷排序:1864
文摘
The cochaperone BAG3 interacts with the mTOR inhibitor TSC1. BAG3 recruits TSC complexes and mTOR vesicles to the actin cytoskeleton. mTORC1 inhibition is essential for BAG3-mediated autophagy at the cytoskeleton. BAG3 activates mTORC1 throughout the cytoplasm and stimulates protein synthesis.