Ti
me spent in sedentary behavior has been associated with worse infla
mmation and cardio
metabolic bio
markers in various populations. However, the association between ti
me spent in sedentary behavior and bio
markers re
mains unknown in patients with inter
mittent claudication. The ai
m of the current study was to analyze the relationship between sedentary behavior and infla
mmatory and cardio
metabolic bio
markers in patients with sy
mpto
matic peripheral arterial disease (PAD).
Methods
The sample included 297 patients with intermittent claudication. Sedentary behavior was assessed using a step activity monitor. Biomarkers of inflammation, oxidative stress, lipid profile, insulin resistance, and endogenous fibrinolysis were assessed. Demographic data, body mass index, physical activity status, and measures of severity of PAD (ankle-brachial index, peak walking time, and ischemic window) also were obtained.
Results
Time spent in sedentary behavior was related with high-sensitivity C-reactive protein (m>bm> = 0.187; m>Pm> = .005), glucose (m>bm> = 0.238; m>Pm> < .001), fibrinogen (m>bm> = 0.167; m>Pm> = .017), plasminogen activator inhibitor 1 activity (m>bm> = 0.143; m>Pm> = .036), and high-density lipoprotein cholesterol (m>bm> = −0.133; m>Pm> = .029). After adjustment for sex, age, physical activity status, body mass index, and severity of PAD, sedentary behavior remained related with high-sensitivity C-reactive protein (m>bm> = 0.170; m>Pm> = .015), glucose (m>bm> = 0.178; m>Pm> = .004), fibrinogen (m>bm> = 0.189; m>Pm> = .010), and high-density lipoprotein cholesterol (m>bm> = −0.128; m>Pm> = .032).
Conclusions
Time spent in sedentary activities was associated with worse inflammatory and cardiometabolic profile in patients with intermittent claudication.