- 作者：Breno Quintella Farah ; Raphael Mendes Ritti-Dias ; Gabriel Grizzo Cucato ; Marcel da Rocha Chehuen ; Jo茫o Paulo dos Anjos Souza Barbosa ; Antonio Eduardo Zeratti ; Nelson Wolosker ; Pedro Puech-Leao
- 刊名：Annals of Vascular Surgery
- 出版年：February, 2014
- 年：2014
- 卷：28
- 期：2
- 页码：279-283
- 全文大小：264 K
Background
Comorbid conditions are known to increase cardiovascular risk in patients with peripheral artery disease (PAD). However, whether comorbid conditions affect walking capacity remains controversial. Previous studies have analyzed comorbidities separately, but they are known to occur in a clustered fashion in PAD patients. Therefore, the aim of this study was to analyze the influence of clustered comorbid conditions on walking capacity in PAD patients.Methods
This cross-sectional study included 415 PAD patients (155 women and 260 men with an average age of 63聽years). Claudication distance and total walking distance were assessed with the graded maximal treadmill test. Medical histories of hypertension, diabetes, cerebrovascular disease (CVD), coronary artery disease (CAD), and chronic obstructive pulmonary disease (COPD) were obtained. Binary logistic regression was carried out to analyze whether clustered comorbid conditions were associated with walking capacity.
Results
CVD was associated with lower total walking distance (odds ratio [OR] = 2.45; 95% confidence interval [CI]: 1.11-5.39). The cluster hypertension, diabetes, CVD, CAD, and COPD were associated with a lower claudication distance (OR = 7.63; 95% CI: 1.42-40.96). In addition, the clusters of CVD and hypertension (OR = 3.16; 95% CI: 1.38-7.23), CVD and CAD (OR聽=聽3.46; 95% CI: 1.25-9.57), CVD, hypertension, and diabetes (OR聽=聽11.38; 95% CI: 2.27-57.00) were associated with a lower total walking distance.
Conclusions
CVD was associated with walking impairment of IC patients and in particular when CVD is clustered with other comorbid conditions.