New dirhodium complex with activity towards colorectal cancer

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• 作者：Raquel F.M. Frade ; Nuno R. C ; eias ; Catarina M.M. Duarte ; Vâ ; nia André ; M. Teresa Duarte ; Pedro M.P. Gois ; Carlos A.M. Afonso
• 关键词：Dirhodium complex ; Human colon adenocarcinoma cells
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2010
• 出版时间：1 June 2010
• 年：2010
• 卷：20
• 期：11
• 页码：3413-3415
• 全文大小：397 K

文摘

A novel dirhodium complex (Rh₂(L-PheAla)₂(OAc)₂ is reported with strong activity towards human colon adenocarcinoma cells. Its effect was not accompanied by generation of reactive oxygen species (ROS) neither by activation of caspase-3.