Toxicological evaluation of magnetic ionic liquids in human cell lines

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• 作者：Raquel F.M. Frade ; ^{rfmf@ff.ul.pt} ; Svilen Simeonov ; Andreia A. Rosatella ; Filipa Siopa ; Carlos A.M. Afonso
• 关键词：Magnetic ionic liquids ; Toxicity ; Cell lines ; Risk assessment
• 刊名：Chemosphere
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：92
• 期：1
• 页码：100-105
• 全文大小：496 K

文摘

Magnetic ionic liquids (MILs) are new solvents with an interesting broad of applications however their toxicity is still an open issue. In this paper we report the toxicity of [C₈MIM] and [Choline-Cm>_nm>] based magnetic ionic liquids assessed in two human cell lines: normal skin fibroblasts (CRL-1502) and colorectal adenocarcinoma cells (CaCo-2), acquiring this last characteristics of human enterocytes after differentiation. The results showed that [CoCl₄] and [MnCl₄] are more prone to generate cytotoxicity.