Prazosin Effects on Objective Sleep Measures and Clinical Symptoms in Civilian Trauma Posttraumatic Stress Disorder: A Placebo-Controlled Study

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• 作者：Fletcher B. Taylor ; Patti Martin ; Charles Thompson ; Judi Williams ; Thomas A. Mellman ; Christopher Gross ; Elaine R. Peskind ; Murray A. Raskind
• 关键词：Nightmare ; posttraumatic stress disorder ; prazosin ; rapid eye movement sleep ; sleep disturbance
• 刊名：Biological Psychiatry
• 出版年：2008
• 出版时间：15 March 2008
• 年：2008
• 卷：63
• 期：6
• 页码：629-632
• 全文大小：95 K

文摘

Studies using facial emotional expressions as stimuli partially support the assumption of biased processing of social signals in social phobia. This pilot study explored for the first time whether individuals with social phobia display a processing bias towards emotional prosody. Fifteen individuals with generalized social phobia and fifteen healthy controls (HC) matched for gender, age, and education completed a recognition test consisting of meaningless utterances spoken in a neutral, angry, sad, fearful, disgusted or happy tone of voice. Participants also evaluated the stimuli with regard to valence and arousal. While these ratings did not differ significantly between groups, analysis of the recognition test revealed enhanced identification of sad and fearful voices and decreased identification of happy voices in individuals with social phobia compared with HC. The two groups did not differ in their processing of neutral, disgust, and anger prosody.