Noradrenergic dysregulation in the pathophysiology of PTSD
详细信息 查看全文
- 作者：Rebecca C. Hendrickson ; rhend@uw.edu" class="auth_mail" title="E-mail the corresponding author ; Murray A. Raskind
- 关键词：Prazosin ; Posttraumatic stress disorder (PTSD) ; Noradrenergic
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：284
- 期：part_PB
- 页码：181-195
- 全文大小：628 K
文摘
- •
Noradrenaline dysregulation plays a critical role in the pathophysiology of PTSD.
- •
Noradrenaline and CRF may interact in regulating amygdala versus mPFC activation.
- •
The α1 adrenergic receptor antagonist prazosin decreases many symptoms of PTSD.
- •
Other alterations in noradrenergic signaling may also contribute to PTSD symptoms.
- •
Evidence suggests heterogeneity in the role of noradrenergic dysregulation in PTSD.