Laminin receptors: achieving specificity through cooperation
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  • 作者:Mercurio ; Arthur M.
  • 刊名:Trends in Cell Biology
  • 出版年:1995
  • 出版时间:November, 1995
  • 年:1995
  • 卷:5
  • 期:11
  • 页码:419-423
  • 全文大小:509 K
文摘
The laminins are a large family of extracellular matrix proteins that can profoundly influence development, differentiation and disease progression. The biological effects of the laminins are mediated by surface receptors that link laminin matrices to intracellular signalling pathways. Several classes of receptors, including integrins and other molecules, may cooperate to provide the specificity apparent in the diverse array of laminin-mediated phenomena. This review assesses our current understanding of laminin receptors and discusses how such receptors could recognize structural differences among the laminins and relay these differences to the cell. valign=""top""> Publisher: valign=""top""> Elsevier Science valign=""top""> Language of Publication: valign=""top""> English valign=""top""> Item Identifier: valign=""top""> S0962-8924(00)89100-X valign=""top""> Publication Type: valign=""top""> Miscellaneous valign=""top""> ISSN: valign=""top""> 0962-8924 valign=""top""> Cited by: valign=""top"">
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Footnotes:
  1. Note: The nucleotide sequence reported in this paper has been submitted to the GenBank/EMBL DataBank with accession number L33460.

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