Multifidone: A novel cytotoxic lathyrane-type diterpene having an unusual six-membered A ring from Jatropha multifida
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- 作者：Biswanath Das ; Kongara Ravinder Reddy ; Bommena Ravikanth ; Tuniki Venugopal Raju ; Balasubramanian Sridhar ; Patan Usman Khan ; Janapala Venkateswara Rao
- 关键词：Jatropha multifida ; Euphorbiaceae ; Multifidone ; X-ray analysis ; Cytotoxicity
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：1 January 2009
- 年：2009
- 卷：19
- 期：1
- 页码：77-79
- 全文大小：232 K
文摘
Chemical examination of the stems of Jatropha multifida afforded a novel lathyrane-type diterpene, multifidone, having an unusual six-membered A ring. The structure of the compound was determined from detailed analysis of its 1D and 2D NMR spectra and X-ray crystallographic analysis. Its cytotoxicity was measured on four different cancerous cell lines.