Synthesis and structure evaluation of a novel cantharimide and its cytotoxicity on SK-Hep-1 hepatoma cells
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- 作者：Stanton Hon Lung Kok ; Chung Hin Chui ; Wing Sze Lam ; Jien Chen ; Fung Yi Lau ; Raymond Siu Ming Wong ; Gregory Yin Ming Cheng ; Paul Bo San Lai ; Thomas Wai Tong Leung ; Michael Wing Yiu Yu ; et al.
- 关键词：Cantharimide ; 2-Aminobenzothiazole ; Neoplasm
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2007
- 出版时间：1 March 2007
- 年：2007
- 卷：17
- 期：5
- 页码：1155-1159
- 全文大小：315 K
文摘
A remarkable control of the potency of cantharimide is described based on the electronic properties of functional group and it exhibits a relatively less toxic effect to the non-malignant hematological disorder bone marrow cells.