Synthesis, characterization and preliminary analysis of in vivo biological activity of chitosan/celecoxib microcapsules
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- 作者：Shuk-Yan Cheng ; Marcus Chun-Wah Yuen ; Pik-Ling Lam ; Roberto Gambari ; Raymond Siu-Ming Wong ; Gregory Yin-Ming Cheng ; Paul Bo-San Lai ; See-Wai Tong ; Kit-Wah Chan ; Fung-Yi Lau ; Stanton Hon-Lung Kok ; Kim-
- 关键词：Celecoxib ; Chitosan ; Cyclooxygenase 2 ; Oral administration
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2010
- 出版时间：15 July 2010
- 年：2010
- 卷：20
- 期：14
- 页码：4147-4151
- 全文大小：784 K
文摘
The use of chitosan as the wall of microcapsule designed for delivery of encapsulated celecoxib is reported. Microcapsules were characterised with respect to size and encapsulation efficiency of celecoxib. In vivo animals demonstrated that both free celecoxib administration and chitosan/celecoxib microcapsules administration lead to a significant inhibition of cyclooxygenase-2 protein expression in the hepatocytes when compared with vehicle control mice. Interestingly, microcapsule containing celecoxib showed a better inhibition of cyclooxygenase-2 protein expression when compared with a simple oral administration of free celecoxib. Gas-chromatography–mass-spectrometry analysis showed that in mice treated with free celecoxib or chitosan/celecoxib microcapsules, their plasma concentration of celecoxib was similar. Microcapsules-based biomaterials as oral drug delivery vehicles may help to improve the absorption efficiency of therapeutic drugs.