The preparation and in vitro antiproliferative activity of phthalimide based ketones on MDAMB-231 and SKHep-1 human carcinoma cell lines
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- 作者：Sau Hing Chan ; Kim Hung Lam ; Chung Hin Chui ; Roberto Gambari ; Marcus Chun Wah Yuen ; Raymond Siu Ming Wong ; Gregory Yin Ming Cheng ; Fung Yi Lau ; Yiu Kwok Au ; Chor Hing Cheng ; Paul Bo Shan Lai ; Chi Wai Kan ; Stanton Hon Lung Kok ; Johnny Cheuk On Tang ; Albert Sun Chi Chan
- 关键词：Anti-tumor activity ; Breast carcinoma ; Hepatoma ; α ; -Phthalimide ketones
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2009
- 出版时间：June 2009
- 年：2009
- 卷：44
- 期：6
- 页码：2736-2740
- 全文大小：435 K
文摘
The ‘one pot’ condensation reaction for the synthesis and potent antiproliferative inhibition of α-phthalimide based ketones is reported here. 2-Phthalimide-1-(4-fluoro-phenyl)ethanone (5) showed the best growth inhibition on human MDAMB-231 breast carcinoma and SKHep-1 hepatoma cell lines. Preliminary studies showed that the reported bioactivity may be due to the presence of strong electronegative fluorine group at the para-position of the aryl ring.