Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus
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- 作者：Kim-Hung Lam ; Roberto Gambari ; Kenneth Ka-Ho Lee ; Yi-Xin Chen ; Stanton Hon-Lung Kok ; Raymond Siu-Ming Wong ; Fung-Yi Lau ; Chor-Hing Cheng ; Wai-Yeung Wong ; Zhao-Xiang Bian ; Albert Sun-Chi Chan ; Johnny Cheuk-On Tang ; Chung-Hin Chui
- 关键词：Antibacterial agents ; Antibiotics ; Quinolines ; Staphylococcus aureus
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：1 January, 2014
- 年：2014
- 卷：24
- 期：1
- 页码：367-370
- 全文大小：1416 K
文摘
This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 渭g/mL as compared to that of methicillin (3.125 渭g/mL) against Staphylococcus aureus.