Pathogenesis of porcine reproductive and respiratory syndrome virus

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• 作者：Ranjni J Chand ; Benjamin R Trible ; Raymond RR Rowland ^{browland@vet.k-state.edu}
• 刊名：Current Opinion in Virology
• 出版年：2012
• 出版时间：June, 2012
• 年：2012
• 卷：2
• 期：3
• 页码：256-263
• 全文大小：379 K

文摘

Porcine reproductive and respiratory syndrome virus (PRRSV) is the most costly viral pathogen facing a modern pig industry. A unique feature of the virus is the ability to cause severe clinical disease and maintain a life-long subclinical infection. Persistence at the population level poses the biggest challenge for the successful control and elimination of the disease. A mechanistic basis for persistence includes the evasion of innate and adaptive immune responses. Recent advances include the study of how the non-structural proteins (nsp's) inhibit the induction of type 1 interferon genes.