Electrochemistry of cytochrome P450 17α-hydroxylase/17,20-lyase (P450c17)

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• 作者：Lisandra L. Martin^a ; ^{Lisa.Martin@monash.edu} ; Clemens Kubeil^a ; Alexandr N. Simonov^a ; ^f ; Vladimir L. Kuznetsov^b ; C. Jo Corbin^c ; Richard J. Auchus^d ; Alan J. Conley^c ; Alan M. Bond^a ; ^f ; Raymond J. Rodgers^e
• 关键词：Steroidogenesis ; Cytochrome P450c17 ; Androgen ; Electron transfer ; Mechanism ; Direct electrochemistry ; CYP17A1 ; Adrenal cortex
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2017
• 出版时间：5 February 2017
• 年：2017
• 卷：441
• 期：Complete
• 页码：62-67
• 全文大小：925 K
• 卷排序：441

文摘

Direct electrochemistry links structure, activity and multi-functionality of P450c17. New methods overcome the challenges for physiologically relevant redox data. FT ac Voltammetry (FTacV) allows new insights to P450 enzyme catalysis.