A Powerful DREADD: Revealing Structural Drivers of Functional Dynamics

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• 作者：Ankit N. Khambhati¹ ; Danielle S. Bassett¹ ; ² ; ^{dsb@seas.upenn.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：DREADDs ; virtual lesioning ; network neuroscience ; functional brain network ; structural brain network
• 刊名：Neuron
• 出版年：2016
• 出版时间：20 July 2016
• 年：2016
• 卷：91
• 期：2
• 页码：213-215
• 全文大小：393 K

文摘

In this issue of m>Neuronm>, Grayson et al. (2016) report how inhibition of amygdala impacts amygdalocortical and corticocortical functional connectivity. Their study predicts changes in functional brain topology, induced by pharmacologic modulation of neuroanatomical circuits using designer receptors exclusively activated by designer drugs (DREADDs), through virtual lesioning of amygdala in structural brain networks.