Blue-yellow perimetry can be an early detector of hydroxychloroquine and chloroquine retinopathy
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- 作者：Mohammad Reza Razeghinejad ; Fatemeh Torkaman ; Heydar Amini
- 刊名：Medical Hypotheses
- 出版年：2005
- 出版时间：2005
- 年：2005
- 卷：65
- 期：3
- 页码：629-630
- 全文大小：34 K
文摘
Complex spinal reconstructive procedures are invariably associated with excessive intraoperative blood loss that significantly increases the risk of severe perioperative complications. In some cases, excessive hemorrhage is equivalent to estimated total blood volume. Unfortunately, widely exposed bony surfaces are not amenable to standard hemostatic maneuvers utilized during soft tissue surgery. This article evaluates the clinical effectiveness of several approaches to blood management in this setting, and hypothesizes that underappreciated topical hemostatic agents may provide benefit by reducing the need for autologous predonation, banked donor blood or antifibrinolytic agents. Topical agents combining collagen, thrombin and fibrin have demonstrated initial promise by inducing platelet aggregation and initiating the clotting cascade when applied directly to bleeding bony sites. Clinical studies are clearly warranted.