CRISPR-mediated targeting of HER2 inhibits cell proliferation through a dominant negative mutation

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• 作者：Huajing Wang ; William Sun ; ^{wsun@ibn.a-star.edu.sg}
• 关键词：Cas9 ; ERBB2 ; Breast cancer ; PARP inhibitor ; Trastuzumab ; Therapeutic
• 刊名：Cancer Letters
• 出版年：2017
• 出版时间：28 January 2017
• 年：2017
• 卷：385
• 期：Complete
• 页码：137-143
• 全文大小：1942 K
• 卷排序：385

文摘

Genomic targeting of HER2 in breast cancer cells by CRISPR/Cas9 inhibited cell growth and tumorigenicity. Effect of CRISPR/Cas9 targeting was enhanced by PARP inhibitors. CRISPR targeting of HER2 unexpectedly resulted in a dominant negative mutation.