A Non-Active-Site SET Domain Surface Crucial for the Interaction of MLL1 and the RbBP5/Ash2L Heterodimer within MLL Family Core Complexes
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- 作者：Stephen A. Shinsky1 ; Michael Hu2 ; Valarie E. Vought2 ; Sarah B. Ng3 ; Michael J. Bamshad3 ; 4 ; Jay Shendure3 ; Michael S. Cosgrove1 ; cosgrovm@upstate.edu" class="auth_mail
- 关键词：MLL ; mixed lineage leukemia ; H3K4 ; histone H3 lysine 4 ; KS ; Kabuki syndrome ; SV-AUC ; sedimentation velocity analytical ultracentrifugation ; GST ; glutathione S-transferase ; MALDI ; matrix-assisted laser desorption/ionization ; TOF ; time-of-flight ; RAD ; RbBP5/Ash2L/DPY-30
- 刊名：Journal of Molecular Biology
- 出版年：12 June 2014
- 年：2014
- 卷：426
- 期：12
- 页码：2283-2299
- 全文大小：1894 K
文摘
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Location of the dimethyltransferase active site on MLL1 core complex is unknown.
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Kabuki syndrome missense mutations cluster on a common SET domain surface.
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KIS is required for interaction with RbBP5/Ash2L.
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KIS amino acids required for formation of second active site in MLL family complexes.