2-(3′,5′-Dimethoxybenzylidene) cyclopentanone, a novel synthetic small-molecule compound, provides neuroprotective effects against ischemic stroke
详细信息 查看全文
- 作者：W.W. Gua ; b ; &dagger ; ; S.Q. Luc ; &dagger ; ; Y. Nia ; b ; &dagger ; ; Z.H. Liud ; X.Y. Zhoua ; b ; Y.M. Zhua ; b ; Y. Luoa ; b ; X. Lia ; b ; L.S. Lia ; b ; W.Z. Sune ; H.L. Zhanga ; b ; huilingzhang07@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; G.Z. Aoa ; b ; aoguizhen@suda.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：COX ; cyclooxygenase ; DMBC ; 2-(3&prime ; 5&prime ; -Dimethoxybenzylidene) cyclopentanone ; DTBHP ; 3 ; 5-di-tert-butyl-4-hydroxyphenyl ; GFAP ; glial fibrillary acid protein ; LDH ; lactate dehydrogenase ; 5-LOX ; 5-Lipoxygenase ; MAP 2 ; Microtubule-associated protein 2 ; MCA ; middle cerebral artery ; OGD ; oxygen&ndash ; glucose deprivation ; PI ; propidium iodide ; pMCAO ; permanent middle cerebral artery occlusion ; rCBF ; relative cerebral blood flow ; tPA ; tissue plasminogen activator ; TTC ; 2 ; 3 ; 5-triphenyltetrazolium
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：316
- 期：Complete
- 页码：26-40
- 全文大小：4651 K
文摘
- •
2-(3′,5′-Dimethoxybenzylidene) (DMBC) produces neuroprotection against pMCAO insult.
- •
DMBC directly protects HT22 cell and astrocytes against OGD insult.
- •
DMBC inhibits the ischemia or OGD-induced activation of cathepsin B.
- •
DMBC treatment blocks the ischemia or OGD-induced release of cathepsin B.