Ambient temperature modulates the effects of the Prader-Willi syndrome candidate gene Snord116 on energy homeostasis

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• 作者：Y. Qi^a ; ^{y.qi@garvan.org.au} ; L. Purtell^b ; M. Fu^a ; K. Sengmany^a ; K. Loh^a ; L. Zhang^a ; S. Zolotukhin^c ; A. Sainsbury^a ; ¹ ; L. Campbell^b ; & H. Herzog^a
• 关键词：Prader-Willi syndrome ; SnorRNAs ; Snord116 ; Energy homeostasis ; Thermoneutrality ; Neuropeptides
• 刊名：Neuropeptides
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：61
• 期：Complete
• 页码：87-93
• 全文大小：1292 K
• 卷排序：61

文摘

Snord116 plays a critical role in the development of Prader-Willi syndrome. Ambient temperature corrects the phenotypes caused by the deletion of Snord116 gene. Ambient temperature corrects the expression of neuropeptide Y and proopiomelanocortin. These alterations are via neuropeptide Y system.