Variants in the DRD2 locus and antipsychotic-related prolactin levels: A meta-analysis
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- 作者：Itaru Miuraa ; b ; Jian-Ping Zhanga ; c ; d ; Katsuhiko Hagia ; e ; Todd Lencza ; c ; d ; f ; John M. Kanea ; c ; d ; f ; Hirooki Yabeb ; Anil K. Malhotraa ; c ; d ; f ; Christoph U. Corrella ; c ; d ; f ; ccorrell@lij.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Antipsychotics ; Prolactin ; Hyperprolactinemia ; Schizophrenia ; DRD2 ; Meta-analysis
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：72
- 期：Complete
- 页码：1-10
- 全文大小：669 K
文摘
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We conducted a meta-analysis of associations between DRD2 variants and PRL levels.
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Eleven studies with a total of 1073 antipsychotic-treated patients were included.
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Overall, we found no associations between the two DRD2 variants and PRL levels.
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In schizophrenia, PRL levels were significantly higher in DRD2 Taq1A A1 carriers.
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DRD2 Taq1A may affect antipsychotic-related PRL levels in schizophrenic patients.