Chemoselective Claisen-Schmidt bis-substitutional condensation catalyzed by an alkoxy-bridged dinuclear Ti(IV) cluster

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• 作者：Yufei Wu^a ; Jie Hou^a ; Yuliang Liu^a ; Mingfu Zhang^a ; Chen-Ho Tung^a ; ^b ; Yifeng Wang^a ; ^{yifeng@sdu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Claisen&ndash ; Schmidt reaction ; Crossed-aldol reaction ; Bis-substituted alkanone ; Dinuclear cluster ; Bis substitution
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：24 March 2016
• 年：2016
• 卷：72
• 期：12
• 页码：1511-1516
• 全文大小：1983 K

文摘

The highly efficient and chemoselective α,α′-bis-substitution of alkanones is important in organic synthesis. Herein, a dimeric titanium cluster, Ti₂Cl₂(OPrⁱ)₆·2HOPrⁱ (Ti₂), is used in the Claisen–Schmidt condensation reaction, for the selectively activation of symmetrical ketones containing α,α′-methylene groups and production of α,α′-bis-substituted alkanones in high efficiency and chemoselectivity. The high efficiency and chemoselectivity can be extended to a variety of typical alkanones and aromatic aldehydes. Both of the oxo-bridged dimeric motif of Ti₂ and the ionic Ti–Cl bond are responsible for the high efficiency and chemoselectivity.