An asymmetric iodolactonization reaction catalyzed by a zinc bis-proline-phenol complex

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• 作者：Liudmila Filippova ; Yngve Stenstr酶m ; Trond Vidar Hansen
• 关键词：Asymmetric synthesis ; Iodolactonization ; 未-Iodolactones ; Trost ligand ; Zinc complex
• 刊名：Tetrahedron Letters
• 出版年：8 January, 2014
• 年：2014
• 卷：55
• 期：2
• 页码：419-422
• 全文大小：604 K

文摘

The intramolecular zinc bis-proline-phenol complex 2a was found to promote enantioselective iodolactonization reactions of both electron-rich and electron-poor 5-aryl-5-hexenoic acids affording 未-iodolactones in good chemical yields with up to 82% enantiomeric excess. The reactions were found to be insensitive to air and moisture, providing an experimentally simple protocol for synthetically useful compounds.