Defining drug response for stratified medicine

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• 作者：Mike Lonergan¹ ; Stephen J. Senn² ; Christine McNamee³ ; Ann K. Daly⁴ ; Robert Sutton⁵ ; Andrew Hattersley⁶ ; Ewan Pearson¹ ; Munir Pirmohamed³ ; ^{munirp@liverpool.ac.uk}
• 刊名：Drug Discovery Today
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：22
• 期：1
• 页码：173-179
• 全文大小：418 K
• 卷排序：22

文摘

Different people can respond differently to similar drug treatment regimes. The risk of adverse drug reactions can also vary between individuals. Stratified medicine uses this variation to identify appropriate treatments. Potential effects of variability need to be considered at the start of studies. Definitions of variability, and methods to assess it, require standardisation.